Curriculum VItae


Moaraj Hasan
 

Email: mohasan@ethz.ch
Phone: +41 76 507 2608
Address: Hinterer Wasen 61

5080 Laufenburg,
Aargau, Switzerland
 


Education

CANDIDATE FOR MASTERS IN BIOTECHNOLOGY

Engineering. Department of Biosystems Science and Engineering
Eth Zürich 2015 - Present

Bachelors of Biochemistry

Science. Department of Chemistry. 
University of Waterloo. 2010 - 2015


Journal Publications

Microsolvation of uranium dioxide

  Moaraj Hasan, Jessie Baldwin, Scott W. Hopkins
  The Journal of Physical Chemistry A. [2015]
  Funding Sources: NSERC[Working Manuscript]

The structures and properties of proton-and alkali-bound cysteine dimers

Christian Ieritano, Patrick JJ Carr, Moaraj Hasan, Michael Burt, Rick A Marta, Vincent Steinmetz, Eric Fillion, Terrance B McMahon, W Scott Hopkins. Physical Chemistry Chemical Physics [2016]

[Access Online]

Targeted Interleukin-10 Nanotherapeutics Developed with a Microfluidic Chip Enhance Resolution of Inflammation in Advanced Atherosclerosis

  Nazila Kamaly, Jun Woo, Jackie Milton, Renata Leito, Christian Iantro, Moaraj Hasan, Ray Chaisson.     American Chemical Society - Nano [ 2015]
  Funding Sources: National Heart, Lung, and Blood Institute [NHLBI] [USA] -  HHSN268201000045C;   National Institutes of Health [NIH] [USA] - CA151884; Prostate Cancer  Foundation [PCF]
  [Access Online]

UNDERSTANDING THE ROLES OF ELECTRONIC AND STERIC EFFECTS IN SEPARATING ISOMERS USING DIFFERENTIAL MOBILITY SPECTROMETRY. 

Chris J. Lock; J. Larry Campbell; Chang Liu1 J.C. Yves Leblanc; Jefry Shields; John Janiszewski; Christian Ieritano; Gene Ye; Gillian Dawes; Moaraj Hasan; W. Scott Hopkins
Journal of the American Society for Mass Spectrometry [2015]
Funding Sources: NSERC
[Submitted Manuscript]

Assessing the impact of anion–π effects on phenylalanine ion structures using IRMPD spectroscopy. 

Michael Burt, Kathleen Wilson, Rick Marta, Moaraj Hasan, Scott Hopkins, Terry McMahon.Physical Chemistry Chemical Physics. 16(44): 24223-24234.  [2014].
Funding Sources: NSERC
[Access Online]

Persistent Intramolecular C–H···X (X = O or S) Hydrogen-Bonding in Benzyl Meldrum’s Acid Derivatives.

W. Scott Hopkins , Moaraj Hasan, Michael Burt, Rick A. Marta, Eric Fillion, and Terry B. McMahon. The Journal of Physical Chemistry A. 118(21): 3795-3803. [2014].
Funding Sources: NSERC
[Access Online]


Work Experience 

  Artistic rendering of BIND pharmaceuticals PLGA-PEG nanoparticle composite functionalized with targeting ligands

Artistic rendering of BIND pharmaceuticals PLGA-PEG nanoparticle composite functionalized with targeting ligands

HARVARD MEDICAL SCHOOL
RESEARCH ASSOCIATE

DR. OMID FAROKHZAD - LABORATORY OF NANOMEDICINE
JAN/2012-SEPT/2014

Synthesize nano-particles conjugated with polymer shielding, active targeting ligands and nuclide trackers to test accumulation, release kinetics and therapeutics indices in vitro and pharmacokinetic and dynamics in vivo
Characterize particle constituents: polymer, drug and ligands of nano-constructs through a combinatorial approach of 2D NMR, DLS, TEM, GPC, Nano-Drop Spectrometry
Perform molecular dynamics simulations to optimize maximize ligand binding interactions in ebola surface receptors

  AB SCIEX 6500 Series instruments which can be with adapted FAIMS-MS technology

AB SCIEX 6500 Series instruments which can be with adapted FAIMS-MS technology

AB SCIEX
INSTRUMENT DEVELOPMENT ASSISTANT

dR. sCOTT hOPKINS & dR. rOBERT hOFFLER
AUG/2013-PRESENT

Aided in the iterative design process of AB Sciex instruments using Ion trajectory calculation in SimIon/Lorrentz, CAD design and gas flow dynamics in Solid Works
Swiftly grasped principles of mass spectrometry to help increase IMS(Ion Mobility Spectroscopy) signal and resolution tenfold through development of clever ion steering and FAIMS technology
Obtained IR-MPD spectra for clusters of interests in Ion Mobility Spectroscopy at the free electron laser facility in Orsay France to validate computational results
Investigate solvation propensities of model analytics in FAIMS system and computationally to develop methods for predicting batch solubility. 
Building a robust model allowing the adaptation of high throughput gas phase solubility screening of candidate drug molecules at Pfizer using trace analyte concentrations

 Highly symmetric water clathrate formation around Uranium Dioxide is a favorable stationary point at 0 ° K

Highly symmetric water clathrate formation around Uranium Dioxide is a favorable stationary point at 0°K

UNIVERSITY OF WATERLOO
gAS PHASE CLUSTER DYNAMICS RESEARCH ASSISTANT

DR. SCOTT HOPKINS, DEPARTMENT OF CHEMISTRY
SEPT/2012-AUG/2013

Performed high fidelity electronic structure calculations on investigating extended hydrogen bonding network in UO22+ nH2O clusters delivering data with crucial design implications in the new CANDU light water nuclear reactors

Sharply increased the efficiency of analysis using LABview and Python programming to automate calculations and management of large datasets, allowing more time to make critical improvements to theoretical methods

 The Diavik Diamond Mine in the North Slave Region of the Northwest Territories, Canada/ The site where the majority of the groups soil samples were taken.

The Diavik Diamond Mine in the North Slave Region of the Northwest Territories, Canada/ The site where the majority of the groups soil samples were taken.

UNIVERSITY OF WATERLOO
EARTH SCIENCE RESEARCH ASSISTANT

DR. DAVID BLOWES, DEPARTMENT OF EARTH SCIENCES
JAN/2012-APR/2012

 

Effectively managed multiple column experiments exploring the geochemistry and contaminant transport of potential environmental contaminants in an effort to build predictive models 

Performed trace metal concentration analysis on zero valent iron(ZVI) based permeable reactive barrier (PRB) in sensitive anoxic and hypoxic conditions

Utilized a variety of molecular biology and biochemical assay techniques to measured potential soil enzyme activities and microbial community structure via 16SrRNA gene and metagenome sequencing

Bridged communication gaps within the the group by creating a Dropbox and centralized spreadsheets to organize team tasks, priorities, hours, standard operating procedures[SOPs] and all archived samples from 1976-2012


Book ChapterS

 Diverse morphologies of processed silk. [Left to Right] A) Silk Elastin Nanoparticle. B) PVA silk microparticle. C) AFM micrograph of dragline spider nanofiber.D) SEM micrograph of a pH induced B.Mori hydrogel. 

Diverse morphologies of processed silk. [Left to Right] A) Silk Elastin Nanoparticle. B) PVA silk microparticle. C) AFM micrograph of dragline spider nanofiber.D) SEM micrograph of a pH induced B.Mori hydrogel. 

Silk and its applications in Drug Delivery

*Moaraj Hasan, *Raymond Chiasson, *Qusai Al Nazer, Nazila Kamaly and Omid C. Farokhzad. [2014]. CRS Book Series- Advances in Delivery Science. 2014. Springer. [Submitted Manuscript] Funding Sources: National Heart, Lung, and Blood Institute (NHLBI) (USA) - HHSN268201000045C; National Institutes of Health (NIH) (USA) - CA151884; Prostate Cancer Foundation (PCF)
[Access Online]


Dissertation Contributions

 Stable hydrogen bonding structures of glutathione in the gas phase and solution elucidated using ab initio molecular orbital theory in combination with a continuum solvent model

Stable hydrogen bonding structures of glutathione in the gas phase and solution elucidated using ab initio molecular orbital theory in combination with a continuum solvent model

SPECTROSCOPIC ANALYSIS OF RESIN-BOUND PEPTIDES: GLUTATHIONE AND FK-13.

Mike Chan. [MastersThesis] Supervisor: William P. Power. Univerity of Waterloo
Contribution: Developed methods for molecular dynamics simulations and performed the subsequent DFT calculations to investigate gas phase structures of glutathione. The generated results were placed in continuum models to corroborate through space interaction seen in NMR studies.
[ PDF ]

INVESTIGATING ANION-QUADRUPOLE INTERACTIONS OF PHENYLALANINE AND FLUORINATED PHENYLALANINE DERIVATIVES USING DENSITY FUNCTIONAL THEORY AND INFRARED MULTIPLE PHOTON DISSOCIATION SPECTROSCOPY.

Kathleen Wilson. [Masters Thesis] Supervisor Terrace H. McMahon. University of Waterloo 
Contribution: Generated the IR-MPD spectra  Centre Laser Infrarouge d'Orsay in Orsay France used to identify spectral features to assign computational determined stationary point geometries.
[PDF]


Presentations

 Dr. Hopkins and I infront of the poster I presented at the Symposium for Chemical Physics in 2013

Dr. Hopkins and I infront of the poster I presented at the Symposium for Chemical Physics in 2013

ANTI-INFLAMMATORY ACTION OF AC2-26 NANOPARTICLES IN HEART DISEASE.
Moaraj Hasan
, Raymond Chaisson. [2014]. Farokhzad Lab Presentation, Harvard Medical School, Boston, United States [Seminar Presentation].
Funding Sources: National Heart, Lung, and Blood Institute [NHLBI] [USA] - HHSN268201000045C; National Institutes of Health [NIH] [USA] - CA151884; Prostate Cancer Foundation [PCF]

 

STRUCTURAL CHARACTERIZATION OF ALKALI METAL CATIONIZED CYSTEINE COMPLEXES.
Christian Ieritano, Moaraj Hasan, Michael Burt, Rick Marta, Terry McMahon and Scott Hopkins. [2014]. Southern Ontario Undergraduate Student Chemistry Conference 2014, Windsor, Canada. [Competitive Seminar Presentation].
Funding Sources: Natural Sciences and Engineering Research Council of Canada [NSERC]


INTEGRATING GPC IN DEVELOPING PLGA-PEG NANOPARTICLE SYSTEMS.
Moaraj Hasan, Raymond Chaisson. [2014].  Farokhzad Lab Presentation, Harvard Medical School, Boston, United States. [Seminar Presentation and Protocol Demonstration of Agilent GPC]


IDENTIFYING ANION-Π INTERACTIONS IN HALIDE-BOUND PHENYLALANINE DERIVATIVES USING IRMPD SPECTROSCOPY. 
Michael Burt, Kathleen Wilson, Rick Marta, Moaraj Hasan, Scott Hopkins and Terry McMahon. [2013]. Symposium on Chemical Physics, Waterloo, Canada. [Seminar Presentation].
Funding Sources: NSERC


PERSISTENT INTRAMOLECULAR C–H···X (X = O OR S) HYDROGEN-BONDING IN BENZYL MELDRUM’S ACID DERIVATIVES. 
Moaraj Hasan , W. Scott Hopkins , Michael Burt , Rick A. Marta , Eric Fillion , and Terry B. McMahon.[2013]. Symposium on Chemical Physics, Waterloo, Canada. [Poster Presentation].
Funding Sources: NSERC
 

PERSISTENT INTRAMOLECULAR C–H···X (X = O OR S) HYDROGEN-BONDING IN BENZYL MELDRUM’S ACID. DERIVATIVES. 
Moaraj Hasan , W. Scott Hopkins , Michael Burt , Rick A. Marta , Eric Fillion , and Terry B. McMahon.[2013].  Annual Trent Conference on Mass Spectrometry, Orillia, Canada. [Seminar Presentation] Funding Sources: NSERC
 

GAS‐ PHASE STRUCTURES OF CHLORIDE‐BOUND PHENYLALANINE DERIVATIVES DETERMINED BY IRMPD SPECTROSCOPY AND COMPUTATIONAL CHEMISTRY.
Travis Ko, Michael Burt, Rick Marta, Moaraj Hasan, Scott Hopkins, and Terry McMahon. [2013]. Trent Conference in Mass Spectrometry, Orilia, Canada. [Poster Presentation]
Funding Sources: NSERC

 

MICROSOLVATION OF URANYL WATER NANOCLUSTERS. 
Moaraj Hasan, Jessie Baldwin, W.Scott Hopkins. [2013]. South Ontario Undergraduate Student Chemistry Conference, Hamilton, Canada. [Placed 1st in Competitive Seminar Presentation] 
Funding Sources: NSERC

 

MICROSOLVATION OF URANYL WATER NANOCLUSTERS.
Jessie Baldwin, Moaraj Hasan, W.Scott Hopkins. [2012]. Presentation for Collaborators at the University of Guelph, Gulph, Canada. A presentation describing a theoretical overview and preliminary results in uranium micro-solvation done at the Hopkins group. 
Funding Sources: NSERC

 

MICROSOLVATION OF URANYL WATER NANOCLUSTERS.
Moaraj Hasan
, Jessie Baldwin, W. Scott Hopkins. [2012]. Symposium of Chemical Physics, Waterloo, Canada.
Funding Sources: (NSERC)


Teaching Experience

Teaching Assistant 
Course Title: Basic Organic Chemistry 1 Laboratory
Department of Chemistry Sept/2013 - Dec/2013

Course Code: CHEM 266L
Course Topic: Organic Chemistry
Course Level: Undergraduate
Section: Selected experiments for students to understand concepts taught in CHEM 266 lecture. This includes structure, nomenclature and reactions of important classes of organic compounds, stereochemistry and its role in reaction mechanisms.
Number of Students: 51
Tutorial Hours Per Week: 3
Lab Hours Per Week: 3

 

Teaching Assistant
Course Title: Introduction to Applied Microbiology
UNIVERSITY OF WATERLOO Jan/2013 - Apr/2013

Course Code: BIOL 241L
Course Topic: Microbiology
Course Level: Undergraduate
Section: Introduction to microbial ecology, environmental microbiology, food microbiology and medical microbiology. This course has an integrated lab component to supplement the lecture material.
Number of Students: 42
Tutorial Hours Per Week: 2
Lab Hours Per Week: 3


Course Development

Supplementary Video Production
Course Title:  Introductory Spectroscopy and Structure
UNIVERSITY OF WATERLOO Sept/2013 - Present

Course Code: CHEM 209
Course Level: Undergraduate
This course covers nature of electromagnetic radiation and an elementary outline of quantum mechanics in one dimension. I developed a series of videos to supplement the lecture material including a review of concepts and worked out examples. 

Number of Students: 170
Number of Video Tutorials: 1 per week / 12 week semester